The HPC² occupies two buildings in the Thad Cochran Research, Technology, and Economic Development Park adjacent to the Mississippi State University campus in Starkville, Mississippi. The HPC building is a 71,000 square foot facility. A second 57,000 square foot HPC²/CAVS facility was completed in 2004. The HPC²/CAVS organization also occupies a 24,000 square foot building near the Nissan manufacturing facility in Canton, Mississippi. An HPC² branch facility at the NASA Stennis Space Center on the Mississippi Gulf Coast facilitates research with other onsite agencies and industries.

An animated fly-thru of the main HPC building is available.